Lisa lost 125lbs. despite having PCOS. The Facts: Insulin resistance is the main reason why its more challenging for you to lose weight with PCOS. We know all too well the frustration of losing weight with PCOS and so many of us want to know how to lose weight with PCOS. Time and again doctors have told us that we need to lose weight to improve our symptoms but they don’t offer any guidelines as to how to do that. Weight loss with PCOS can feel virtually impossible! There are a number of factors that make losing weight with PCOS really difficult. Here is why. Metformin is usually used for treating high blood sugar. This article takes a look at whether it's a good idea to take metformin for weight loss. Your comment has been the only helpful answer to why I'm possibly gaining weight on metformin instead of losing. I'm on it for pcos and endrinologists don't know that I've seen. I was diabetic but i had bariatric surgery and about 48 hours later my blood sugar levels went down to a normal range. I still take metformin to help with weight loss. Metformin (Glucophage) is a pharmaceutical drug originally developed to treat elevated blood glucose levels in people with Type 2 Diabetes. It is now commonly prescribed for women with PCOS. For many women, weight gain is a symptom of pcos and is a frustrating side effect. Get some great ideas for how to eat for success and feel better. PCOS is an infertility condition that often causes acne, facial hair growth, balding, low sex drive, weight gain, difficulty with weight loss, and mental health disturbances such as depression and anxiety in approximately 15% of women. It is also associated with a myriad of health conditions This article will show you what you need to know about taking metformin if you have PCOS.